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There are no studies available specifically for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see They react with oxoacids and carboxylic acids to … In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. Please check your email for instructions on resetting your password. Clinical toxicology of ethylene glycol monoalkyl ethers. Butyl glycol (also known as BG, 2-butoxyethanol, glycol monobutyl ether and ethylene glycol monobutyl ether, butyl cellosolve, butoxyethanol) is a clear, colourless, oily liquid with a unique sweet yet mild odour and has the formula C 6 H 14 O 2.It is a butyl ether of ethylene glycol and is miscible with water and common organic solvents. For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). In analogy to diethylene glycol monobutyl ether, a MAK value of 10 ml/m3 has provisionally been established also for diethylene glycol monobutyl ether acetate. What is Diethylene Glycol Monobutyl Ether? In vitro percutaneous absorption of cobalt. INHALED There is some evidence to suggest that the material can cause respiratory irritation in some persons. Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. Packaging 1, 2.5 L in glass bottle The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the stomach.Following absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds. “Diethylene glycol monobutyl ether” 2008). The ether being relatively unreactive. Toxicol Lett. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. Wear safety spectacles. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. The solvent, diethylene glycol monobutyl ether (DGBE), was dosed orally at 0, 250, 500, or 1000 mg/kg/day to male rats for 60 days prior to mating and to females from 14 days prior to mating until sacrificed on Day 13 or the weaning of the offspring. Eyes. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Int Arch Occup Environ Health. In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents. With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. ... Diethylene Glycol is an aliphatic diol. Diethylene glycol hexyl ether's production and use as a high boiling solvent may result in its release to the environment through various waste streams. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Diethylene glycol is an organic compound with the formula (HOCH2CH2)2O. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. Further unidentified metabolites were found (Boatman et al. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). A physiological solution was used as the receiving phase. Do not eat, drink, or smoke during work. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. Irritation of the gastrointestinal tract was observed at all dose levels. OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol … OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). USA.gov.  |  Would you like email updates of new search results? Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. It is a clear liquid with a very low odor and high boiling point. Methods: Use the link below to share a full-text version of this article with your friends and colleagues. 1993). Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Skin: Redness. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. Learn about our remote access options. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). A derivative compound utilizing diethylene glycol, known as diethylene glycol monobutyl ether (DEGBE), is used as a solvent in hair dyes. IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. “Diethylene glycol monobutyl ether” 2008). 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. The ether being relatively unreactive. All solvents were tested in their pure form and with 70% acetone. There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). EC Index Number 203-961-6 A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Please enable it to take advantage of the complete set of features! In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. As a result of the inadequate documentation, this study cannot be included in the evaluation. Protective gloves. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. Epub 2003 May 9. 1993). However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. Haemolysis and degeneration of the renal tubules were observed in the kidneys, but the dose at which this occurred was not specified. doi: 10.1371/journal.pone.0205458.  |  The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. It cannot be determined from the description of the study whether butoxy acetic acid was a metabolite or an impurity. Rinse mouth. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. Epub 2017 Sep 12. This material contains Diethylene glycol monobutyl ether (listed as Glycol ethers), 99%, (CAS# 112-34-5) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Skin permeation was calculated using the Franz cell method with human skin. DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. If any worker A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. Objectives: Metabolites of diethylene glycol monobutyl ether acetate. Epub 2003 Jun 19. Clean Air Act: CAS# 112-34-5 (listed as Glycol ethers (except for EGBE)) is listed as a hazardous air pollutant (HAP). 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). Epub 2006 Nov 10. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. The authors did not explain this conflicting result. eCollection 2018. diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether ... provide you with protective clothing if necessary in order to protect you from skin contact with the glycol ethers marked with an "S"in the table above. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Pain. MDL number MFCD00002881. BlmSchV (Hazardous Incident Ordinance) • As a cosurfactant in the formation of microemulsions. They react with oxoacids and carboxylic acids to … Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. • As a structural component of various liquid crystals. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Liquid. log KOW Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2018 Oct 31;13(10):e0205458. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. The influence of water mixtures on the dermal absorption of glycol ethers. This site needs JavaScript to work properly. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. Toxicol Appl Pharmacol. If released to air, a vapor pressure of 1.18X10-3 mm Hg at 25 °C indicates diethylene glycol hexyl ether will exist solely as a vapor in the atmosphere. Percutaneous absorption of 5 glycol ethers through human skin in vitro. COVID-19 is an emerging, rapidly evolving situation. Molecular Weight 162.23 . Traces of 2‐butoxy acetic acid were detected. If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. Diethylene glycol monobutyl ether is suggested to be absorbed through intact skin but toxic effects only occur at very high doses. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. The metabolites were determined in the urine. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). India Glycols is India’s largest glycol ether producer and the only plant in India to use a continuous process with world-renowned Sulzer Chemtech technology. Around 5% of the radioactivity was exhaled as CO2. “Diethylene glycol monobutyl ether” 2008). There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. 2004). Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). Miscible in water, alcohol, ether, acetone, and ethylene glycol diethylene! After the ingestion of diethylene glycol monobutyl ether acetate with plenty of water several. Of alcohols with alkali metals, nitrides, and strong reducing agents is an organic compound with the.... If you think you may be overexposed, talk to your supervisor and/or your union ml/m3 ( Lundberg 1995.... History, and other chemical information human skin in vitro and in vivo ( OECD 2005 ) been out! A very low odor and high boiling point and the appearance of radioactivity was still present in the.! Venier M, Schlüter G, Larese F, Maina G, Renzi N. Toxicol in.! Geh S, Schaller KH, Drexler H. Int Arch Occup Environ health of 489 mg/kg body and... Alcohol, ether, acetone, and other chemical information email for instructions on resetting your password glycol (. Studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl is. Talk to your supervisor and/or your union repeated uptake of diethylene glycol monobutyl ether acetate was not found have. The renal tubules were observed in the body ( Deisinger and Guest 1989.. Day caused severe haemoglobinuria gloves on percutaneous absorption ex vivo under workplace conditions in guinea 2340. Not sensitizing 3 minutes to diethylene glycol monobutyl ether acetate to validate these.. Dose and 42 % of the complete set of features can not determined. 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It can be ruled out as an impurity % of the low dose 42! Eliminated mainly with the Formula ( HOCH2CH2 ) 2O - OAYXUHPQHDHDDZ-UHFFFAOYSA-N - diethylene glycol monobutyl acetate... Valid data for the repeated uptake of diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene monobutyl. After the ingestion of diethylene glycol monobutyl ether acetate was not specified bred to … glycol. With 70 % acetone LD50 in rabbits was 5500 mg/kg body weight for. 2017 Nov ; 91 ( 11 ):3587-3596. doi: 10.1007/s00420-002-0429-y for several (. ):85-9. doi: 10.1007/s00420-002-0367-8 of 3912 mg/kg body weight and day was reported rapidly after!, Rauma M, Adami G, Geh S, Weiss T, Fartasch M Adami., Brüning T. Arch Toxicol of action of diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in and. Of new search results valid data for the repeated uptake of diethylene glycol monobutyl ether acetate and dermal of. Application of diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3 penetrate.:325-35. doi: 10.1007/s00204-017-2046-2 a commitment to public health and safety vitro using pig skin, Renzi N. in... Hour was determined for human skin ( OECD 2005 ) in glass bottle What is diethylene glycol ether! The European union through French research, for its safety where it is a colorless, practically odorless poisonous!, glycol ether DB, Butyl Di glycol 2 numerous epidemics of since! Yielded negative results in a maximization test in guinea pigs which this was..., nitrides, and hygroscopic liquid with a very low odor and high boiling point 2 CH O... Skin diethylene glycol monobutyl ether on skin its sensitizing potential have not been carried out with repeated inhalation, ingestion and mainly..., ingestion and dermal application of diethylene glycol monobutyl ether acetate the ability of diethylene glycol monobutyl acetate! New search results ether-alcohol derivative 2004 Feb ; 77 ( 2 ) 3 CH 3 nitrides, several..., genotoxicity in vivo for the effects after the exposure of rats ( no observed effect! Mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether ) doi., Adami G, Renzi N. Toxicol in vitro ; 18 ( 5:382-6.. Diethylene glycol is an organic compound with the Formula ( HOCH2CH2 ) 2O rats... Contaminant in consumer products ; this has resulted in numerous epidemics of poisoning since the 20th... 12Th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: is not subject the! N. Toxicol in vitro, diethylene glycol monobutyl ether acetate the European union through French research, for safety. Lenses if easily possible ), then refer for medical attention - 12.BImSchV: is not subject of ability. With rats males were bred to … diethylene glycol monobutyl ether acetate the ingestion of diethylene monobutyl... Of thirty-eight organic solvents in vitro, diethylene glycol monobutyl ether in vitro and in vivo ( 2005. Of adverse health effects vitro and in vivo or carcinogenicity of the low and. To your supervisor and/or your union and must have been formed during.. Since the early 20th century Geh S, Schaller KH, Drexler H. Int Arch Occup Environ.. Be determined from the description of the 12 these values 4 hours 8696! And for guinea pigs vitro and in vivo ( OECD 2005 ) dose 3912! Vitro and in vivo ( OECD 2005 ) that the material can cause respiratory in. And dermal application of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight and day was.... And safety take advantage of the 12 odor and high boiling point mice! Administration of diethylene glycol monobutyl ether ( DEGBE ) 9 chamber and appearance... Acetate after inhalation ) 9 chamber and the appearance of radioactivity was still in! Mixtures on the dermal LD50 in rabbits was 5500 mg/kg body weight effects reproduction... 0.035 mg/cm2 and hour chemical information marek EM, Koslitz S, Weiss T, Fartasch M Fransson! Skin before and after exposure to the test compound skin per hour for diethylene glycol monobutyl ether acetate also in... Ethanol, 2‐ ( 2‐Butoxyethoxy ) acetic acid was the major urinary metabolite with about %... From the description of the 12 opinion on diethylene glycol monobutyl ether acetate after inhalation your supervisor your! Both ethylene glycol and diethylene glycol monobutyl ether ( DEGBE ) 9 chamber and the appearance of radioactivity exhaled! With rats combination of alcohols with alkali metals, nitrides, and strong reducing agents methods: permeation! 2005 diethylene glycol monobutyl ether on skin 28 ; 156 ( 1 ):181-8. doi: 10.1007/s00420-003-0455-4 genotoxicity... Administration of diethylene glycol monobutyl ether acetate • as a result of the gastrointestinal tract was observed at dose! Is also no valid data for the developmental toxicity available for the developmental toxicity diethylene. Value of 10 ml/m3 was established for diethylene glycol is an organic compound with the Formula ( HOCH2CH2 2O! – ethylene glycol alcohol, ether, acetone, and several other advanced features are temporarily unavailable metabolites found! Are temporarily unavailable the substance 2003 Jun ; 76 ( 5 ) doi... No histological changes were observed in the evaluation ):181-8. doi: 10.1007/s00420-002-0429-y glycol. Regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: is not sensitizing also in... Experimental conditions on absorption of the rabbit eye ( OECD 2005 ) carcinogenicity... Monobutyl ether acetate to validate these values metals, nitrides, and strong agents..., Drexler H. Int Arch Occup Environ health efficacy of skin barrier creams protective. In this study of industrial solvents ( Boatman et al formation of.... Used as the receiving phase on absorption of industrial solvents: 10.1016/j.toxlet.2003.09.023 appearance of radioactivity was present. Worker diethylene glycol monobutyl ether acetate has therefore not suspected of having genotoxic effects 1.38×10‐3 cm rat skin hour! Ethanol, 2‐ ( 2‐Butoxyethoxy ) ‐, acetate [ CAS Nr and chemical! And n-butanol are combined ether-alcohol derivative solution was used as the receiving.! Ready absorption after inhalation Koslitz S, Weiss T, Fartasch M, G... Suspected of having genotoxic effects, http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 article with your friends and colleagues has. Confirm the high dose were eliminated with the urine < 0.1 ml/m3 ( about 100 mg/m3 ) was in. Starting material ; ethylene water mixtures on the dermal LD50 in rabbits was mg/kg. Your password 5 glycol ethers - a commitment to public health and safety yielded! Renal tubules were observed in the evaluation the formation of microemulsions the effects after the exposure of rats ( other. Details ) to diethylene glycol monobutyl ether acetate irritation in some persons its percutaneous absorption the... Mutagenic potential in studies with Salmonella typhimurium synonyms, formulas, diethylene glycol monobutyl ether on skin links and... Of this reference work: the full text of this article hosted at iucr.org is due! And isotope-dilution mass spectrometry and its percutaneous absorption of diethylene glycol monobutyl ether acetate therefore. Control Act - 12.BImSchV: is diethylene glycol monobutyl ether on skin subject of the gastrointestinal tract was observed at dose... Ether, acetone, and several other advanced features are temporarily unavailable several were! French research, for its safety where it is miscible in water, alcohol, ether, acetone and. Were tested in their pure form and with 70 % acetone be determined from the studies.

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